UniProt ID (Human) P31749. PHLPP1 134 diseases associated Protein phosphatase involved in regulation of Akt and PKC signaling. General protein kinase capable of phosphorylating several known proteins. Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis and tumor formation. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues in the carboxy-terminal sequence of mouse Akt.
RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1_HUMAN.
Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is activated by C-terminal phosphorylation. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. The RCSB PDB also provides a variety of tools and resources. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane. LY294002 is a specific PI3 kinase inhibitor (11). Akt is one of the most actively studied kinase pathways in the basic research and drug development arenas, as it plays an integral role in mediating signals for cell growth, survival, cell-cycle progression, differentiation, transcription, translation, and glucose metabolism. PTEN phosphatase is a major negative regulator of the PI3 kinase/Akt signaling pathway (10). Another essential Akt function is the regulation of glycogen synthesis through phosphorylation and inactivation of GSK-3α and β (12,13). Protein Names. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including Bad (7), forkhead transcription factors (8), c-Raf (9), and caspase-9. PTEN phosphatase is a major negative regulator of the PI3 kinase/Akt signaling pathway (10). RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1_HUMAN. Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Thr308 of mouse Akt. UniProt Code History. From UniProt: AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. B2RAM5, B7Z5R1, P31749, Q9BWB6.
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RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1_HUMAN.
Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is activated by C-terminal phosphorylation. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. The RCSB PDB also provides a variety of tools and resources. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane. LY294002 is a specific PI3 kinase inhibitor (11). Akt is one of the most actively studied kinase pathways in the basic research and drug development arenas, as it plays an integral role in mediating signals for cell growth, survival, cell-cycle progression, differentiation, transcription, translation, and glucose metabolism. PTEN phosphatase is a major negative regulator of the PI3 kinase/Akt signaling pathway (10). Another essential Akt function is the regulation of glycogen synthesis through phosphorylation and inactivation of GSK-3α and β (12,13). Protein Names. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including Bad (7), forkhead transcription factors (8), c-Raf (9), and caspase-9. PTEN phosphatase is a major negative regulator of the PI3 kinase/Akt signaling pathway (10). RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1_HUMAN. Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Thr308 of mouse Akt. UniProt Code History. From UniProt: AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. B2RAM5, B7Z5R1, P31749, Q9BWB6.
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