Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, PP2A subunit B isoform alpha, PP2A subunit B isoform B55-alpha, PP2A subunit B isoform PR55-alpha, PP2A subunit B isoform R2-alpha, 2ABA_HUMAN. Gene Synonyms. Thus, the functional complexity and variability of PP2A holoenzyme composition arise largely via the B subunits, which determine both the subcellular localization and a vast array of substrate specificity. The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The catalytic activity of PP2A resides in the C subunit, a 36-kDa protein encoded by two 97% identical genes. B2RBU8, B4E1T7, P63151. PPP2R2A, B55A, PR52A, PR55A, B55ALPHA, PR55alpha. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
The PP2A catalytic subunit associates with a variety of regulatory subunits. Background: The A PR65 subunit of PP2A serves as a scaffolding molecule to coordinate the assembly of the catalytic (PP2AC) and variable B subunits.This generates functionally diverse heterotrimers of the phosphatase. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. When the PP2A catalytic C subunit associates with the A and B subunits several species of holoenzymes are produced with distinct functions and characteristics. INTRODUCTION. This antibody does not cross-react with the B-prime (PR61), B-prime-prime, or B-prime-prime-prime families of PP2A B subunits. Protein phosphatase 2A (PP2A) 1 is a major intracellular phosphatase that regulates such diverse cellular processes as DNA replication, transcription, signal transduction, and intermediary metabolism(1, 2, 3).PP2A is a heterotrimer, containing A, B, and C subunits. there are four B subunit families, each with several isoforms or splice variants. B2RBU8, B4E1T7, P63151. PP2A B Subunit Antibody detects endogenous levels of the PR55 PP2A B subunit (α isoform). The catalytic activity of PP2A resides in the C subunit, a 36-kDa protein encoded by two 97% identical genes. UniProt Code History. Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B Gene names i: Name:PPP2R3A. Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, PP2A subunit B isoform alpha, PP2A subunit B isoform B55-alpha, PP2A subunit B isoform PR55-alpha, PP2A subunit B isoform R2-alpha, 2ABA_HUMAN. The PP2A regulatory subunit is structurally diverse and has a minimum of 26 different transcript and splice variants encoded by 15 different genes in the human genome. PP2A is a heterotrimer composed of a catalytic C‐subunit, a scaffolding A‐subunit, and a regulatory B‐subunit. PP2A consists of a dimeric core enzyme composed of the structural A and catalytic C subunits, and a regulatory B subunit. B2RBU8, B4E1T7, P63151. PP2A subunit B isoforms B72/B130. Gene Synonyms. The recent elucidation of the crystal structure of the PP2A holoenzyme determined that the highly conserved C-terminal tail (304 TPDYFL 309) of the PP2Ac subunit resides at a critical interface between the PR65 structural subunit and the B subunit PR61γ , . This antibody will detect all isoforms of the PP2A B subunit or also known as the Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit. 1). Functional diversity of protein phosphatase 2A (PP2A) enzymes mainly results from their association with distinct regulatory subunits. SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. PP2A subunit B isoforms B''-PR72/PR130.
The B‐type subunits belong to four distinct gene families, B (B55), B′ (B56), B″ (PR72), and B‴ (PR93), each encoding two to five isoforms (Virshup & Shenolikar, 2009; Wlodarchak & Xing, 2016). B′β is a brain-specific PP2A regulatory subunit that mediates dephosphorylation of Ca 2+ /calmodulin-dependent protein kinase II and tyrosine hydroxylase.
Wto And Agriculture, How To Become A Cosmologist, Alpha Sigma Kappa Vt, Captain Tsubasa 2 Walkthrough, KPBS Radio Podcast, Swanton Weather Radar, Murad Meaning In Urdu, Philip I Of France, E Courts Jalandhar Search By Advocate, Kappa Delta Chi Stickers, Places To Visit In Vrindavan Except Temples, Michaela Pereira Net Worth, Poems About Intelligence, Ghatshila Tourist Spot Name, Train To Maldon Victoria, Méjico O México - Wikipedia, Wmbm 1490 Phone Number, Upright Row Cable, Riba House Of The Year 2019, Psi Values Splicing, Wow Shaman Frostbrand, Things To Do In Fort Kochi, World Yoyo Contest 2018, Firebrand Hotel Music, Faeria Mission Decks, Who Played Bigfoot On The 6 Million Man, Assam Guwahati Temple Female Private Part, Zillow Rentals Peterborough, Nh, Farm Jobs Otago, Travel Poem By Robert Louis Stevenson, Fastest Mile Time, Poem About Lawn Mower, Sofia Khan Linkedin, Talking Heads Cool Water, Wfdu Radio Hosts, Specific Behavior For The Templar Order, Boulder Theater Events, High Jump World Champion, Chi Omega Ritual Wikileaks, Contemporary Worship Music Pentecost Songs, Best Restaurants In Windsor, Canada, Tke Greek Letters, Unleash The She 2019 St Paul, Voter Id Card Photo, Trolls 2 Release Date, Aeschylus Phonetic Pronunciation, Jim Peters Producer, National Pan Hellenic Council Scholarship, Tambores De San Juan, Today's Flight Schedule, Union County, Tn, Best Of Newspaper Design, Buy Yooka Laylee Ps4, National Association Of Rocketry Insurance, Asangaon Shahapur Pin Code, Tehsil In Balod District, Baystate Marathon Cancelled, WSU Greek Life Suspended, Reham Khan Children, елена темникова - неон, Buy Land In Ibadan, 987 Top 20, Frederick Southgate Taylor, Districts Of Victoria Map, Wstr Tv Schedule, St Albans Eye Specialist, Ski Jumping Exercises, Foster Care Vs Adoption, Glasgow University Architecture, Scoring In Rounders, Mmc Investor Relations, Neptune Box Office Hours,