BIRB 796 is a highly potent inhibitor of p38 MAPK.
In vitro: BIRB 796 is a picomolar inhibitor of human p38 MAP kinase with a 12,000-fold increase in binding affinity. - Find MSDS or SDS, a COA, data sheets and more information. Furthermore, BIRB 796, a p38α/β inhibitor that is structurally unrelated to SB compounds, similarly prevents TNT-induced gene expression changes. Turner et al Matrix Biol 2010;29:613-620). and/or the p38 MAPK inhibitor BIRB-796 (0.1–1000 nM, Sigma) and incubated in 5% CO 2 at 37 °C for varying time points.Plateswere centrifuged at 2000rpm for 10min at4°C and cell-free supernatants removed and stored at −80°C for cytokine analysis. Home>>Signaling Pathways>> MAPK Signaling>> Raf>>BIRB 796 (Doramapimod) BIRB 796 (Doramapimod) Catalog No.GC11497 P38 MAPK inhibitor,cell permeable and highly selective BIRB 796 is a highly potent inhibitor of p38α and β, at low nmol/l concentrations in kinase assays (Pargellis et al, 2002; Regan et al, 2002; Kuma et al, 2005). p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem p38 MAP Kinase Inhibitor X, BIRB 796, CAS 285983-48-4, is a cell-permeable, highly potent, slow binding, high affinity inhibitor of p38a (IC50 = 8 and 97 nM with or without 2 h preincubation). The p38 MAPK inhibitor, BIRB 796, was provided by Boehringer Ingelheim Pharmaceuticals Inc. (Ridgefield, CT, USA), dissolved in DMSO, and stored at −80°C until use. We routinely use 10 uM SB203580 for inhibiting p38-alpha/beta, and 1 uM BIRB-0796 for inhibiting all 4 p38 subtypes in cell culture models (e.g.

Background & Aims: The p38 mitogen-activated protein kinase (MAPK) regulates the expression of proinflammatory cytokines, which play a critical role in the pathophysiology of Crohn’s disease (CD).

The p38 MAPK inhibitor, BIRB 796, was provided by Boehringer Ingelheim Pharmaceuticals Inc. (Ridgefield, CT, USA), dissolved in DMSO, and stored at )80 C until use.

This study investigated the efficacy and safety of BIRB 796, a highly potent inhibitor of p38 MAPK, in chronic active CD.

BIRB 796 is a highly potent inhibitor of p38a and b, at low nmol/l concentrations in kinase assays (Pargellis et al, 2002; Regan et al, 2002; Kuma et al, 2005). AhRPE treated with TNT and BIRB …

Moreover, BIRB 796 behavors as one of the most potent and slowest dissociating human p38 MAP kinase inhibitors now known [1].

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