Control of the phosphorylation of the astrocyte marker glial fibrillary acidic protein (GFAP) in the immature rat hippocampus by glutamate and calcium ions: possible key factor in astrocytic plasticity . GFAP (Astrocyte & Neural Stem Cell Marker); Clone GA-5 & ASTRO/789 (Concentrate) Species: Mouse Immunogen: GFAP isolated from pig spinal cord (GA-5); Recombinant GFAP protein (ASTRO/789) Clone: GA-5 & ASTRO/789 Isotype: IgG1 (GA-5); IgG1 (ASTRO/789) Species Reactivity: Human, Mouse, Rat, Cow, Pig, Rabbit, Chicken. Hippocampal subfields were also assessed for GFAP-immunoreactive area fraction.
R. Rodnight, C.A. However, its expression tends to be more prevalent in white matter. It acts as an astrocyte-specific marker.

GFAP is a well-defined marker widely used in vivo and in vitro applications. Positive Control: Brain or … GFAP is the most commonly used astrocyte marker, but it only labels a small portion of astrocytes in the normal mouse cortex (Wang and Walz, 2003; Sofroniew and Vinters, 2010; Molofsky et al., 2012). GFAP antibodies are the most popular marker for astrocytes in neurological studies and along with its breakdown products (BDPs), GFAP has been proposed as a useful candidates for biofluid-based markers for numerous neurological conditions especially during traumatic brain/spinal cord injury and stroke [1]. Gonçalves, S.T. 1978). In addition to the application of GFAP as a routine identi-fier of astrocytes in the healthy CNS, the molecular cloning of mouse Gfap (Lewis et al., 1984) led to the use of increased Gfap gene expression (or increased GFAP protein) in astrocytes as the standard marker of astrocyte reactivity.

The density of GFAP-immunoreactive astrocytes was measured in the hippocampus using 3-dimensional cell counting. Neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of normal and reactive astrocytic cells and neural stem cells. Markers for mature astrocytes include aldehyde dehydrogenase family 1 member L1 (Aldh1L1) , aldolase C (AldoC) , glutamate transporter-1 (Glt1) , S100 calcium-binding protein B (S100b) and Aquaporin 4 . Particularly, GFAP expression, often used as a reliable astrocyte marker, is not always expressed by astrocytes and is more common to reactive and white matter astrocytes. Visit the Together with microtubules and microfilaments, it forms the Glial fibrillary acidic protein (GFAP) belongs to class III intermediate filaments (IFs) and is specifically expressed in the cytoplasm of central nervous system astrocytes (AS). Wofchuk and R. Leal.
In addition, S100β has been shown to label astrocytes, but it is also expressed by oligodendrocytes and their progenitors ( Steiner et al., 2007 ). Gfap… Others not known. Sections from the body of the hippocampus were immunostained for glial fibrillary acidic protein (GFAP), a marker of intermediate filament protein expressed in astrocytes. GFAP is also a major component of the “glial scar”, an astrocyte rich structure that can inhibit nerve fiber regeneration following damage in the central nervous system.


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