Okadaic acid (OA) can be used to induce an Alzheimer's disease (AD) model characterized by tau hyperphosphorylation, the formation of neurofibrillary tangles formation and β‑amyloid (Aβ) deposition. }, author={Yi-peng Wang and Xian-tao Li and Shi-jie Liu and Xin-wen Zhou and Xiao-Chuan Wang and Jian-Zhi Wang}, journal={Acta pharmacologica Sinica}, year={2004}, volume={25 3}, … Keywords: okadaic acid, Alzheimer’s disease, tau phosphorylation, wortmannin, organotypic brain slices, transgenic mice. Keywords:Okadaic acid, Alzheimer’s Disease, Zebrafish, Tau & phospho-Tau protein, Amyloid β, glycogen synthase-3α/β &, phospho-GSK-3α/β, senile plaque. Jian-zhi Wang. [3] [20] Furthermore, in two-stage carcinogenesis of mouse skin, the molecule and its relatives have been shown to have tumor promoting effects. Search for more papers by this author. @article{Wang2004MelatoninAO, title={Melatonin ameliorated okadaic-acid induced Alzheimer-like lesions. Melatonin ameliorated okadaic-acid induced Alzheimer-like lesions. Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid‐treated SY5Y cells.
One of the primary causes of diarrhetic shellfish poisoning, okadaic acid is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. Yunn Chyn Tung. Previous studies have shown that the upregulation of Beclin‑1‑dependent autophagy may contribute to the elimination of aggregated Aβ. Okadaic acid (OKA), a potent inhibitor of PP1 and PP2A, reportedly leads to cognitive decline and Alzheimer's disease (AD)-like pathology. Corpus ID: 7479360. Citation: Foidl BM and Humpel C (2018) Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. By using electron microscopy, Western blotting, and immunocytochemistry, here we show that autophagosomes are accumulated in rat neurons by okadaic acid (OA), a protein phosphatase‐2A inhibitor known to enhance tau phosphorylation, β‐amyloid (Aβ) …
Pathophysiology Department, Tongji Medical College, HUST, 13 Hong Kong Road, Hubei, Wuhan 430030, PR China . E-mail address: wangjz@tjmu.edu.cn. PDF | Despite the many years of extensive research using rodent models to study Alzheimer's disease (AD), no cure or disease halting drug exists. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid. Okadaic acid has been shown to have neurotoxic, immunotoxic, and embryotoxic effects. Okadaic acid, C 44 H 68 O 13, is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish.
Department of Neurochemistry, New York … Autophagosomes are accumulated in Alzheimer's disease (AD), but the regulatory pathway of autophagy in AD remains largely unknown. Abstract:Alzheimer’s disease (AD) is the leading neurodegenerative disorder affecting the world’s elderly population.
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