The stimulation of glycogen-targeted protein phosphatase 1 (PP1), glycogen synthase, and glycogen synthesis by insulin was examined during the differentiation of 3T3-L1 fibroblasts into adipocytes.

The Role of Protein Phosphatase-1 in Insulin Action MATTHEW J. BRADY AND ALAN R. SALTIEL Department of Cell Biology, Parke-Davu Pharmaceutical Research Division, 2800 Plymouth Road, Ann Arbor, Michigan 4810s ABSTRACT Insulin is the most-potent physiological anabolic agent known, promoting the synthesis and Overactivation of phosphatases is one possible means of blocking insulin signaling. PTP1B has been implicated in negatively regulating the IR as well as its substrates, such as IRS-1 and -2, by dephosphorylating them (10–12).

Protein phosphatase 1 (PP1) is one of four major types of serine-threonine phosphatases mediating signaling pathways, but the means by which its activity is modulated has only recently begun to … Protein phosphatase 1 (PP1) is one of the major phosphatases responsible for protein dephosphorylation in eukaryotes.

One key phosphatase, protein tyrosine phosphatase 1B (PTP1B), is a target for treatment of type 2 diabetes. Reversible protein phosphorylation is a major regulatory mechanism of intracellular signal transduction. Insulin treatment barely changed the low levels of glycogen synthesis measured in fibroblasts. So far, only few specific phosphorylation sites of PP1 regulatory subunit 12A (PPP1R12A) have been shown to regulate the PP1 activity. Cell Reports Article The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition QiqiLi,1 QiuyeZhao,1 JunyuZhang,1 LinkangZhou,1 WenhaoZhang,1 BoonTinChua,2 YanChen,3 LiXu,1,*andPengLi1,4,* 1State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Protein phosphatase 1 (PP1) belongs to a certain class of phosphatases known as protein serine/threonine phosphatases.This type of phosphatase includes metal-dependent protein phosphatases (PPMs) and aspartate-based phosphatases.PP1 has been found to be important in the control of glycogen metabolism, muscle contraction, cell progression, neuronal activities, splicing of …

The effect of insulin on PPP1R12A phosphorylation is largely unknown. The critical role of protein phosphorylation in the regulation of glucose and lipid metabolism has been recognized since the pioneering work of Krebs and Fischer in the 1950s ().Insulin modulates many of the metabolic rate-limiting enzymes by promoting their net dephosphorylation, due to the activation of the type 1 serine-threonine protein phosphatase 1 (PP1) ().

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