Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Medium tumor antigen-associated 61 kDa protein, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha, 2AAA_HUMAN. 71978 Ensembl ENSG00000221914 ENSMUSG00000022052 UniProt P63151 Q6P1F6 RefSeq (mRNA) NM_001177591 NM_002717 NM_001205188 NM_028032 NM_001360033 NM_001360034 RefSeq (protein) NP_001171062 NP_002708 NP_001192117 NP_082308 NP_001346962 NP_001346963 Location (UCSC) Chr 8: 26.29 – 26.37 Mb Chr 14: 67.01 – 67.07 Mb PubMed search Wikidata …
Physical form Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
UniProt Code History. The B″/PR72 family of protein phosphatase 2A (PP2A) is an important PP2A family involved in diverse cellular processes, and uniquely regulated by calcium binding to the regulatory subunit.
PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit (PR65) (subunit A). PP2A is the major phosphatase for microtubule-associated proteins (MAPs). Immunoflourescent staining of paraformaldehyde fixed HeLa cells, using PP2A A Subunit Antibody.
MonoclonalAnti-PP2A, C subunit antibody produced in mouse has been used in immunoblotting and immunoprecipitation. P30153, Q13773, Q6ICQ3, Q96DH3.
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human PP2A C subunit protein. UniProt Number: P67775; UniProt Summary: ... SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits.
Polyclonal Antibody for studying PP2A C subunit in the Phosphatases research area. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (subunit A), that associates with a variety of regulatory subunits such as subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families) (By similarity). - Find MSDS or SDS, a COA, data sheets and more information.
総説 PP2A 阻害因子を標的とした抗がん戦略の可能性 295 トーシス促進性のBimやBadに対しては脱リン酸化す ることで発現や活性を上昇させることが報告されてい る(17, 18). 3.
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of It is also thought to be the principal downmodulator of Ser/Thr kinase cascades.
The AC dimer recruits a third regulatory B subunit that has been predicted to dictate the substrate specificity and function of the PP2A heterotrimeric complex. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (EC 3.1.3.16; UniProt P67775; PP2A-alpha, PP2Ac, PP2Calpha, Replication protein C, RP-C) is encoded by the PPP2CA (also known as PP2CA) gene (Gene ID 5515) in human. Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. Biological Information Immunogen peptide corresponding to the C-terminal amino acid PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and its high sensitivity to Okadaic Acid.
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